(3 credits) Prerequisite: Graduate standing in chemical engineering or permission of instructor. The application of engineering principles to the analysis and control of air pollution includes techniques of air sampling and analysis, atmospheric chemistry and transport, air quality standards, and methods of air pollution abatement.
(3 credits) Prerequisite: Graduate standing in chemical engineering or biology, or permission of instructor. Introduction to the fundamental concepts in biochemical engineering. Topics include enzyme kinetics, immobilized enzymes, genetic engineering, cell growth kinetics, and batch and continuous reactor design.
(3 credits) Prerequisite: Graduate standing in chemical engineering or permission of instructor. Isothermal and non-isothermal analysis of kinetic data for gas-solid catalytic and non-catalytic reacting systems. Design of packed bed, fluidized bed, and moving bed reactors.
(3 credits) Prerequisites: Graduate standing in Chemical Engineering or Permission of
Instructor. Connection between mechanics and thermodynamics, statistical mechanics. Intermolecular forces. Basic principles, molecular dynamics and Monte Carlo simulation. Corresponding states and phase equilibrium from molecular simulation. Optional special topics. Examples of computer codes. Students who have passed CHE 478 may not register for CHE 578.
(3 credits) Prerequisite: Graduate standing in chemical engineering or permission of instructor. Develops a foundation in combustion phenomena, including transport and other mechanisms in homogeneous and heterogeneous combustion. Environmental implications of combustion. Elementary modeling and preliminary design calculations in industrial and modern applications of combustion, such as hazardous waste incineration, gas turbines, catalytic converters, and coal combustion systems. Regulatory concerns, stoichiometry, thermochemistry, incinerators, and air pollution control.
(3 credits) Prerequisite: Graduate standing in chemical engineering or permission of instructor. Emphasis on polymer molecular structure and its relation to physical properties, such as molecular weight distributions, gel point, glass transition, heat capacity, and viscosity. Other topics include polymerization kinetics; condensation esterification; emulsion polymerization; and methods of analysis, such as X-ray diffraction, infrared spectroscopy, and other important basic engineering properties of polymers.
(1-3 credits) Prerequisite: Admittance to Accelerated Program, or permission from the Program. Advanced selected topics in Chemical and Biomedical Engineering. Offered on sufficient demand. May be repeated for credit with change of topic. Cross-listed with BME 594.
(1-3 credits) Prerequisites: Admittance to Accelerated Program, or permission from the Program. Student will be involved in an engineering research or development project under the personal supervision of a faculty member. The specific responsibilities of the student will be arranged by mutual consent of the student, the student’s research advisor, and the department’s graduate advisor. May be repeated for credit.
(3 credits) Prerequisite: CHE 504 or equivalent. Advanced reaction engineering principles applied to the design and operation of multiphase reactors. Multiple reactions and heat effects in gas-solid, gas-liquid, and gas-solid-liquid reacting systems. Optimization of chemical reactors.
(3 credits) Prerequisite: CHE 504 or equivalent. Consideration of the fundamentals of homogeneous and heterogeneous reacting systems. Discussion of kinetic mechanisms, non-isothermal kinetics, enzyme kinetics, and solid phase reactions.
(3 credits) Prerequisite: CHE 506 or equivalent. Investigation of theory and methods of heat transfer of interest to chemical engineers. Topics include transient conduction, thermal boundary layer, forced convection, free convection, and radiative heat transfer.
(3 credits) Prerequisites: CHE 504, CHE 506, and CHE 582, or equivalents. Examination of systems that utilize combustion for generation of mechanical and thermal energy for specific applications. Representative systems, such as turbines and fluid bed units, are examined in detail.
(3 credits) Modern numerical procedures in approximation theory, matrix eigenvalues, initial and boundary value problems, and partial differential equations. Skill in selecting appropriate procedures for particular problems is developed. Required projects consist of programming solutions to engineering problems.
(3 credits) Prerequisite: CHE 616 or equivalent. An introduction to optimization theory and methods. Examination of the application to process design. Study of the formulation of the engineering optimization problem. A design optimization project is required.
(3 credits) Prerequisites: CHE 502 and CHE 504. In-depth study of solid catalysts and catalytic process analysis and design. Kinetics of elementary steps and overall reactions. Kinetics of two-step reactions on non-uniform surfaces. Structure-sensitive and structure-insensitive reactions. Parasitic phenomena.
(3 credits) Prerequisite: Graduate standing in chemical engineering or permission of instructor. Understanding the terms and concepts of biomechanical engineering as it relates to medical needs and patients, including topics in artificial joints, mechanics and modeling of soft tissue, properties of blood, cardiac valves, heart function and heart assist replacement, biomechanical issues in rehabilitation equipment and prosthetics, renal function, and oxygen transport. Cross-listed with BME 651.
(3 credits) Prerequisite: Graduate standing in chemical engineering or permission of instructor. Essential concepts and technologies in cellular and molecular biology, as relevant to the design, application, and evaluation of biological constructs in tissue engineering, with preliminary understanding of commercial applications. Cross-listed with BME 653.
(3 credits) Prerequisite: Graduate standing in chemical engineering or permission of instructor. An introduction to materials in medicine designed to develop an understanding of the terms and concepts that relate basic and applied biomaterials engineering research to medical devices. Cross-listed with BME 655.
(3 credits) Prerequisite: Graduate standing in engineering or permission of instructor.
A practical approach to learning the process and principles for medical device
design. Students will learn the basic concepts of designing medical devices and through a hands-on approach. Teams of students will work together on a design project including concepts such as needs identification, FDA regulation, record-keeping, reverse engineeing, human factors, prototyping, and validation. Cross-listed with BME 658.
(3 credits) Prerequisite: Graduate standing in chemical engineering or approval by instructors. Introduction to the principles of X-Rays, Ultrasound, Radio nuclide Imaging, and Magnetic Resonance Imaging: Description of data acquisition and image reconstruction techniques; Introduction to image processing techniques; Clinical applications and industrial procedures and regulations. Cross-listed with BME 659.
(3 credits) Prerequisites: Graduate standing in engineering or approval by instructor. Signals and biomedical signal processing; the Fourier transform; image filtering, enhancement, and restoration; edge detection and image segmentation; wavelet transform; clustering and classification; processing of biomedical signals; processing of biomedical images. Cross-listed with BME 670.
(3 credits) Prerequisites: CHE 658 Medical Device Design and graduate standing in engineering or consent of instructor. This is a two-semester course and students must take both courses in sequence to receive a grade. Students will work in teams over the two semesters to identify a medical device need, perform a market analysis, and develop a working prototype for the product.
(3 credits) Prerequisites: CHE 658 Medical Device Design and graduate standing in engineering or consent of instructor. This is a two-semester course and students must take both courses in sequence to receive a grade. Students will work in teams over the two semesters to identify a medical device need, perform a market analysis, and develop a working prototype for the product.
CHE 692 - Chemical and Biomedical Engineering Internship
(1 credits) Prerequisites: Graduate standing, completion of at least one full-time academic year in the Masters in Chemical Engineering/Doctor of Engineering Program, and permission of advisor. This course is intended to provide students with practical experience in chemical or biomedical engineering. Students will be required to submit periodic progress reports, in addition to submitting a Final Project Report at the end of the term. May be taken up to two times for credit. Graded on a pass/fail (S/U) basis. Cross-listed with BME 692.
(1-4 credits) Prerequisite: Graduate standing in chemical engineering or permission of instructor. Advanced selected topics in chemical engineering. Offered on sufficient demand. May be repeated for credit with change of topic. Cross-listed with BME 694.
(1-4 credits) Prerequisite: Graduate standing in chemical engineering or permission of instructor. Analysis of a specific problem in an area of mutual interest to the student and instructor. A formal written report is required.
(1-12 credits) Prerequisite: Graduate standing in chemical engineering or permission of instructor. The Thesis/Dissertation proposal approval form must be on file in the College of Graduate Studies prior to enrollment. Research under the guidance of a faculty member, culminating in the writing of a thesis.
(3 credits) Prerequisite: CHE 504 or equivalent. Consideration of the fundamentals of homogeneous and heterogeneous reacting systems. Discussion of kinetic mechanisms, non-isothermal kinetics, enzyme kinetics, and solid phase reactions.
(3 credits) Prerequisite: CHE 506 or equivalent. Investigation of theory and methods of heat transfer of interest to chemical engineers. Topics include transient conduction, thermal boundary layer, forced convection, free convection, and radiation heat transfer.
(3 credits) Prerequisite: CHE 510 or equivalent. Gibbs phase rule binary diagrams and their correlation with Gibbs free energy; influence of pressure on binary diagrams. Ternary equilibrium diagrams for condensed systems. Methods of presentation of equilibrium diagrams of four and more components.
(3 credits) Prerequisites: CHE 504, CHE 506, and CHE 582, or equivalents. Examination of systems that utilize combustion for generation of mechanical and thermal energy for specific applications. Representative systems, such as turbines and fluid bed units, are examined in detail.
(3 credits) Prerequisite: CHE 716 or equivalent. An introduction to optimization theory and methods. Examination of the application to process design. Study of the formulation of the engineering optimization problem. A design optimization project is required.
(3 credits) Prerequisites: CHE 502 and CHE 504. In-depth study of solid catalysts and catalytic process analysis and design. Kinetics of elementary steps and overall reactions. Kinetics of two-step reactions on non-uniform surfaces. Structure-sensitive and structure-insensitive reactions. Parasitic phenomena.
(3 credits) Understanding the terms and concepts of biomechanical engineering as they relate to medical needs and patients, including topics in artificial joints, mechanics and modeling of soft tissue, properties of blood, cardiac valves, heart function and heart assist replacement, biomechanical issues in rehabilitation equipment and prosthetics, renal function, and oxygen transport. Cross-listed with BME 751.
(3 credits) Prerequisite: Standing in Engineering Doctoral program. Essential concepts and technologies in cellular and molecular biology, as relevant to the design, application, and evaluation of biological constructs in tissue engineering with preliminary understanding of commercial applications. Cross-listed with BME 753.
(2 credits) Prerequisite: Graduate standing in Engineering or permission of instructor.
The process and principles of medical device design, including concepts such as needs identification, FDA regulation, intellectual property, record-keeping, reverse engineering, human factors, prototyping, and validation. Cross-listed with BME 758.
(3 credits) Prerequisites: Graduate standing in Engineering or permission of the instructor. Signals and biomedical signal processing; the Fourier transform; image filtering, enhancement, and restoration; edge detection and image segmentation; wavelet transform; clustering and classification; processing of biomedical signals; processing of biomedical images. Cross-listed with BME 770.
(1-4 credits) Prerequisite: Standing in Engineering Doctoral program or permission of instructor. Advanced selected topics in chemical engineering. Offered on sufficient demand. Cross-listed with BME 794.
(1 credits) Prerequisites: Graduate standing in Engineering or permission of the instructor. A seminar series presenting current research in biomedical engineering. Topics may include kinesiology, tissue biomechanics, cardiovascular devices, tissue engineering, modeling metabolism, medical imaging, bioMEMS, biosensors, cellular therapy, neural control, advanced biomaterials, automated recording keeping, etc. Cross-listed with BME 850.
(1-12 credits) Prerequisite: Standing in Engineering Doctoral program or permission of instructor. Analysis of a specific problem in an area of mutual interest to the student and instructor. A formal written report is required. Up to 10 credits may be used toward the dissertation credit requirement.
(1-12 credits) Prerequisite: Successful completion of candidacy examination. The dissertation proposal approval form must be on file in the College of Graduate Studies prior to enrollment. Research under the guidance of a faculty member, culminating in the writing of a dissertation.
(3 credits) Prerequisite: CHM 332, Organic Chemistry II. Chemistry of carbohydrates, lipids, proteins, nucleic acids, vitamins and hormones, with major emphasis on biochemical processes in human cells and organs, enzyme kinetics.
(3 credits) Prerequisite: CHM 502, Biochemistry I. Metabolism of carbohydrates, lipids, proteins, nucleic acids, vitamins and hormones, with major emphasis on metabolism within human cells.
(3 credits) Prerequisite: CHM 331 or equivalent. Chemical aspects of environmental problems: energy, air, and water pollution; solid waste; toxic substances; and related topics.
(3 credits) Prerequisite: One year of natural sciences or permission of instructor. Various topics on the impact of environmental pollutants on humans.
(3 credits) Prerequisite: CHM 311 or equivalent; co-requisite: CHM 516. Advanced theory and techniques of modern instrumental analysis with emphasis on optical spectroscopies, potentiometry, amperometry, and coulometry.
(3 credits) Prerequisite: CHM 411 or CHM 511. A general overview of the prevalent chemical principles, methods, and instrumentation involved in the analysis of physical evidence.
(3 credits) Prerequisites: CHM 332 and 337 or their equivalent. Corequisite : CHM 402 is strongly recommended. First of a two-course sequence in pharmacology. General aspects of pharmacology, drug effects on the nervous system and neuroeffectors, psychopharmacology, depressants and stimulants of the central nervous system, anesthetics, drugs used in cardiovascular diseases, drug effects on the respiratory tract, drugs that influence metabolic and endocrine functons, chemotherapy, principles of toxicology, etc.
(3 credits) Prerequisite: CHM 541. Second of a two-course introduction to pharmacology. Study of human disease processes and the specific rational pharmacotherapeutics relating to the cardiovascular, respiratory, renal, hematologic, and dermatologic systems as well as eyes, ears, nose, and throat. Specific drug’s indications, contraindications,mechanism of action, side effects, dosages, and methods of administration will be presented.
(3 credits) Prerequisites: CHM 332 and 337 or their equivalent. Corequisite: CHM 402 is strongly recommended. First of a two-course sequence in medicinal chemistry. Structure-activity relationships, molecular features of drugs, mechanisms of drug action, design and development of drugs, drug names and nomenclature, and therapeutic applications of drugs.
(3 credits) Prerequisite: CHM 310 and CHM 315 or CHM 311 and CHM 316 or equivalent courses. This course provides hands-on experience for the major instrumentation and techniques used in the analysis of pharmaceuticals and biopharmaceuticals. The laboratory experiments involve the analysis of drug molecules by atomic emission spectroscopy, fluorometry, infrared spectroscopy, nuclear magnetic resonance spectroscopy, gas chromatography, liquid chromatography, and mass spectrometry, as well as methods of sample preparation.
(1-2 credits) This course will provide the content, knowledge and skills of scientific inquiry necessary for teaching chemistry in 7th through 12th grades.
(3 credits) Prerequisites: All other courses required for forensic chemistry certificate. Practical experience at a relevant, off-campus forensics lab.
(1-6 credits) Prerequisite: Permission of instructor. Discussion of selected topics in chemistry as determined by faculty and student interest. Offered occasionally.
(1 credits) Prerequisite: Approval of instructor. Orientation to the philosophy and methods used in teaching chemistry; observation and directed practice teaching in the laboratory and classroom.
CHM 604 - Special Topics In Environmental Chemistry
(3 credits) Prerequisites: CHM 504 and approval of advisor. Discussion of special topics in environmental chemistry, reflecting student and faculty interests.
(3 credits) Prerequisite: Approval of advisor. Discussion of special topics in analytical chemistry, reflecting student and faculty interests. May be repeated for credit with chnage of topic.
(3 credits) Prerequisite: CHM 511 or equivalent. Theoretical principles of analytical chemistry, including equilibrium, error analysis, and quantitative calculations.
(4 credits) Prerequisite: CHM 511 or prior approval of the Faculty instructor. Theory, principles, and applications of electroanalytical chemistry. Electron transfer in molecular mechanisms and molecular imaging, sensors, and state-of-the-art devices for analysis and diagnosis. Theory and application of advanced scanning probe techniques including AFM, STM, Scanning Electrochemical Microscopy (SECM), and coupled AFM-electrochemical analysis.
(4 credits) Prerequisite: CHM 511 or equivalent. Comprehensive survey of separation techniques, including solvent extraction, gas chromatography, liquid chromatography, supercritical fluid chromatography, chromatography detectors, gel electrophoresis, and capillary electrophoresis.
(3 credits) Prerequisite: Approval of advisor. This course covers electrospray, MALDI, CI, APCI, EI, and other novel ionization methods, as well as quadruple, TOF, FTMS, and double sector mass spectrometry. GC/MS and LC/MC also are discussed.
(4 credits) Prerequisite: Approval of Advisor or one year of undergraduate physical chemistry. Principles of quantum theory including aspects of structure and spectroscopy. Will include projects using common quantum computational software programs.
(4 credits) Prerequisite: CHM 631/731 or approval of instructor. Discussion of special topics in organic chemistry reflecting student and faculty interests. May be repeated for credit with change of topic.
(4 credits) Prerequisite: CHM 332 or equivalent. Structure and properties of organic compounds, including stereochemistry, conformational analysis, aromaticity, reactions, and reaction intermediates.
(4 credits) Prerequisite: CHM 631/731. A study of the mechanisms of organic reactions and their implications in synthetic and structural organic chemistry.
(4 credits) Prerequisite: Approval of advisor. Discussion of special topics in inorganic chemistry, reflecting student and faculty interests. Currently, bioinorganic chemistry and inorganic nanotechnology are the modern topics. Examples from the newest chemical literature will be discussed.
(4 credits) Prerequisite: CHM 441 or equivalent. Application of chemical kinetics, thermodynamics, and elementary quantum chemistry to the determination of mechanisms of inorganic reactions; structural aspects of inorganic reactivities. Introduction to bioinorganic chemistry. Applications cover almost every element and examples from the newest chemical literature.
(4 credits) Prerequisite: CHM 625/725 or equivalent. Symmetry and group theory of inorganic and organometallic compounds; irreducible representations and character tables; applications to valence-bond and molecular-orbital theories of chemical bonding, structures, and spectroscopy. Applications cover examples from the newest chemical literature.
(4 credits) Laboratory diagnosis of kidney, liver, and hemolytic diseases. Instruction includes physiology and pathophysiology in conjunction with laboratory testing for the above diseases. Laboratory statistics also are covered.
(4 credits) Laboratory investigations of disorders in acid-base balance, lipid and carbohydrate metabolism, and endocrine functions. Biochemical markers of myocardial infarction. Case studies.
(4 credits) Prerequisite: CHM 332 or CHM 402. Chemistry of proteins, carbohydrates, and lipids; immunology and AIDS. Enzyme and energetics of metabolic reactions.
(4 credits) Prerequisite: CHM 653. Metabolism of nitrogen-containing compounds, vertebrate metabolism, neurotransmission, nucleotides, and nucleic acids, DNA processes, RNA synthesis and processing, protein synthesis, gene expression, and cancer.
(4 credits) Techniques of immunoassays and techniques of isolation, manipulation, and analysis of proteins/nucleic acids are covered. Includes both lecture and laboratory.
(6 credits) Prerequisite: Approval of the Director of Clinical Chemistry. Students rotate through the clinical laboratory at Cleveland medical centers, being trained in instrumentation, quality control, and diagnostic uses of various testing methodologies. Students are assigned evaluations and/or development projects for a more in-depth experience. Management issues of the clinical laboratory also are addressed. Offered in the summer to clinical chemistry majors only.
(4 credits) Prerequisites: Undergraduate organic chemistry, physical or analytical chemistry or prior permission of the Faculty instructor. Survey of basic and advanced analytical techniques that are critical in investigations of structure and dynamics of biomolecules, including protein, DNA and RNA folding and structures and function. Examination of biomolecules using basic and ADVANCED techniques including spectroscopic, time-resolved, and molecular imaging techniques.
(1-11 credits) Prerequisite: Approval of advisor. An advanced laboratory program in selected techniques to be determined by the needs and interests of the student. Offered every semester.
(1 credits) Prerequisite: Departmental Approval. Written report and oral presentation of research progress to student’s Research Advisor and Thesis/Dissertation Committee; includes submission of figures and data, and receiving feedback from the Advisor and the Committee.
(1 credits) Prerequisites: Graduate standing, completion of at least one full-time academic year in the Chemistry MS program or in the Clinical-Bioanalytical Chemistry PhD program, and permission of advisor. Provides students with practical experience in chemical and its applied fields. Students are required to submit a final project report and make an oral presentation at the end of the course. May be repeated one time for credit. Graded on an S/U basis.
(1 credits) Introduction to effective collection, organization, and presentation of technical information. Students are required to present seminars, preferably dealing with some aspect of their proposed research program.
(1-16 credits) Prerequisite: Departmental approval. Methods and techniques of experimental research under the direction of a faculty advisor; includes submission of an acceptable thesis. Offered every semester.
(1 credits) Prerequisite: Approval of instructor. Orientation to the philosophy and methods used in teaching chemistry; observation and directed practice teaching in the laboratory and classroom.
CHM 704 - Special Topics In Environmental Chemistry
(3 credits) Prerequisites: CHM 504 and approval of advisor. Discussion of special topics in environmental chemistry, reflecting student and faculty interests.
(3 credits) Prerequisite: Approval of advisor. Discussion of special topics in analytical chemistry, reflecting student and faculty interests. May be repeated for credit with change of topic.
(3 credits) Prerequisite: CHM 511 or equivalent. Theoretical principles of analytical chemistry, including equilibrium, error analysis, and quantitative calculations.
(4 credits) Prerequisite: CHM 511 or prior approval of the Faculty instructor. Theory, principles, and applications of electroanalytical chemistry. Electron transfer in molecular mechanisms and molecular imaging, sensors, and state-of-the-art devices for analysis and diagnosis. Theory and application of advanced scanning probe techniques including AFM, STM, Scanning Electrochemical Microscopy (SECM), and coupled AFM-electrochemical analysis.
(4 credits) Prerequisite: CHM 511 or equivalent. Comprehensive survey of separation techniques, including solvent extraction, gas chromatography, liquid chromatography, supercritical fluid chromatography, chromatography detectors, gel electrophoresis, and capillary electrophoresis.
(3 credits) Prerequisite: Approval of advisor. This course covers electrospray, MALDI, CI, APCI, EI, and other novel ionization methods, as well as quadruple, TOF, FTMS, and double sector mass spectrometry. GC/MS and LC/MC also are discussed.